Designed for the smallest patients
Tyke features a thin, pliable design ideal for intracardiac and arterioplasty procedures. Easy to suture—even in fragile anatomy—and designed for confident handling in small, high-risk patients.
- Promotes tissue regeneration for native tissue-like vessel and cardiac repair
- Shown to reduce reintervention compared to synthetic alternatives.
Usage:
- For use in neonates and infants for arterioplasty procedures, particularly pulmonary artery repair, as well as venoplasty and general vascular reconstruction (for delicate vessels ≤12 mm diameter and pressures <50 mmHg)
- Additional Applications: Intracardiac repairs (e.g., septal or annulus repair), valve reconstruction, pericardial repair, and epicardial covering
Proven Regenerative Healing
PERFORM Study: 221 patients with iliofemoral artery repair
Carotid Registry: 45 cases of carotid artery reconstruction (38 patients)
Histological evaluation confirms Tyke’s capacity for integration with native host tissue. In a 12-year-old patient following pulmonary artery reconstruction, the graft underwent complete remodeling. At the graft–native vessel interface, seamless integration and minimal inflammatory infiltrate were observed—findings indicative of true structural incorporation (figures below).
Tyke not only delivers structural support, but also facilitates true tissue regeneration, preserving vessel integrity and functionality.
Histology of Remodeled Tyke in Pulmonary Artery at 12 Months2
Twelve-year-old patient who underwent pulmonary artery reconstruction.
Figure 1:
Masson’s trichrome stain shows organized collagen and spindle-shaped cells aligned with the vessel wall, along with a continuous endothelial lining and preserved vascular structure.
Figure 2:
The graft–native vessel junction demonstrates seamless integration, aligned tissue architecture, and minimal inflammation.
Elutia’s Biomatrices for Cardiovascular Tissue
The Natural Choice for Repair and Regeneration
Elutia’s biomatrix portfolio is built on engineered extracellular matrix (ECM) biology—designed to facilitate surgical repair, support healing, and address key causes of complications.
Trusted in over one million patients and supported by hundreds of peer-reviewed publications, Elutia’s ECM biomatrices offer confidence in every repair.
Naturally Better
Unlike other products that are crosslinked—compromising their ability to remodel—Elutia’s biomatrices preserve what matters for healing.
Clinical Experience in Infected and High-Risk Surgical Fields*
Elutia’s biomatrices (ProxiCor, VasCure) have been used for valve and annular repair in patients with endocarditis, as well as in high-risk conditions such as prior infection or radiation. Though based on limited number of patients, these cases showed no infection-related failures and good tissue integration—supporting potential use in contaminated or compromised fields.7,9,10
*ProxiCor, VasCure and Tyke are not specifically cleared or indicated by regulatory authorities for the prevention or treatment of infection. Clinical judgment should guide their use in infected or high-risk surgical fields.
Trusted by surgeons. Validated by data. Naturally.
1. Allen K, et al. Front Cardiovasc Med. 2021;8:631750.
2. Bibevski S, et al. Front Cardiovasc Med. 2020;7:562136.
3. Ferng A, et al. Ann Thorac Surg. 2017;104(3):e239–e241.
4. Grimes M, et al. Biomed Mater Eng. 2005;15(1–2):65–71.
5. Haney L, et al. Ann Thorac Surg. 2021;S0003-4975(21)01384 undermann S, et al. Interact Cardiovasc Thorac Surg. 2015;20(1):10–14.
8. Elutia Data on File.
9. Myers P, et al. Circulation. 2012;126:A16130.
10. Gerdisch M, et al. J Thorac Cardiovasc Surg. 2014;148(4):1370–1378.
11. Badylak S, et al. J Biomed Mater Res B Appl Biomater. 2003;67(1):648–654.
12. Jernigan T, et al. Ann Surg. 2004;239(5):733–738.