For Cardiovascular Repair

Tyke is the Only Extracellular Matrix Cleared for Neonates & Infants.

The natural choice in neonatal and infant cardiovascular repair.

An extracellular matrix (ECM) derived from porcine small intestine submucosa (SIS), Tyke regulates the biologic healing response to decrease inflammation and stimulate formation of healthy tissue.^2,3,4,5 Tyke is used for neonatal and infant patch, pledget, and intracardiac repair, and provides a natural extracellular matrix (ECM) bioscaffold that promotes regeneration of the patient’s own cells to form healthy, site-specific tissue.^1,6

Benefits of Tyke.

2-Ply ECM specifically designed to be thinner
and more pliable for neonatal and infant procedures
Remodels to restore healthy, native tissue⁶
Resistant to calcification¹
Ideal for long-term repairs

Meets Physician Need.

“The ultimate goal in congenital cardiac surgery is to achieve a physiologic and durable repair that has the potential for growth. An ideal material for the reconstruction of congenital heart malformations would possess a number of essential properties. This material would be pliable, handle easily, and would not calcify over time. It would be suitable to be used in both intracardiac and extracardiac repairs and would encourage regeneration of native tissue. Finally, it would have the potential for growth appropriate in relation to somatic growth of the patient.”

Scholl FG, et al. World J Pediatr Congenit Heart Surg. 2010;1(1):132-136.

Better Surgical Experience.

Tyke is a 2-ply extracellular matrix specifically created for neonate and infant repairs.

Aziyo Tyke Product Features and Benefits

Tyke has shown lower re-intervention rates when compared to bovine and synthetic patches, thus lowering the overall cost of care and may provide better patient and family experience.⁷

Publication

Preliminary experience with cardiac reconstruction using decellularized porcine extracellular matrix scaffold: human applications in congenital heart disease

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Product Brochure

Learn more about Tyke and why we created a 2-ply material for cardiovascular repair for neonates and infants.

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Publication

More Than 400 Uses of an Intestinal Submucosal Extracellular Matrix Patch in a Congenital Heart Program

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Product Specifications

Sizing and Ordering Information

Product Numbers are for U.S. only.

wdt_ID	Product Number	Width (cm)	Height (cm)
1	CMCV-098-204	4	7
3	CMCV-099-204	4	7

Download Instructions for Use (IFU)

IFU for U.S. only.

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Interested in Tyke?

Learn About Tyke Today!

To schedule a product demo or request an in-service for a product evaluation, reach out to your area sales representative or contact us.

Yes, I'm Interested!

1. Data on file at Elutia Inc.
2. Pre-clinical data on file at Elutia Inc.
3. Dziki JL, et al. J Biomed Mater Res A. 2017;105(1):138–147.
4. Badylak SF, et al. J Surg Res. 2002 Apr;103(2):190-202.
5. Brennan E, et al. Tissue Eng. 2006 Oct;12(10):2949-55.
6. Scholl FG, et al. World J Pediatr Congenit Heart Surg. 2010;1(1):132-136.
7. Hollabaugh W, et al. An Appraisal of Materials and Value for Patch Reconstruction of the Pulmonary Arteries. Conference presentation abstract CHSS 2017, October.

WMK-1505-01D